A UPS cargo plane crashed early Wednesday morning near Louisville Muhammad Ali International Airport, killing at least nine people and injuring eleven others, according to local authorities. The aircraft, reportedly a Boeing 767 operated by UPS Airlines, went down shortly after takeoff, erupting into flames upon impact in a residential area close to the airport’s southern perimeter.
Emergency crews from Louisville Metro Fire, Police, and EMS responded swiftly, extinguishing the fire and evacuating nearby homes. Several injured residents were transported to University of Louisville Hospital, where some remain in critical condition.
The news out of Louisville is tough tonight as the death toll has now reached at least 7, with that number expected to rise. First responders are onsite and working hard to extinguish the fire and continue the investigation. 1/3
— Governor Andy Beshear (@GovAndyBeshear) November 5, 2025
However, Federal investigators from the National Transportation Safety Board (NTSB) and the Federal Aviation Administration (FAA) have launched an investigation to determine the cause of the crash. Preliminary reports suggest possible engine failure, but officials have not confirmed the cause.
An aircraft incident occurred at SDF today at approximately 5:20 p.m. involving a UPS MD-11, flight no. 2976 when departing the West Runway (17R/35L) to the Daniel K. Inouye International Airport (HNL) in Honolulu, HI. Emergency crews are on-scene at SDF. At this time, all…
— FlyLouisville (SDF) (@FlyLouisville) November 4, 2025
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UPS released a statement expressing deep sorrow over the loss of its employees and extending condolences to the victims’ families. Louisville Mayor Craig Greenberg praised the quick response of first responders and promised full cooperation with federal authorities as recovery efforts continue. The crash has temporarily disrupted flight operations at Louisville International Airport, UPS’s main global air hub.
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